Adult stem cells from bone marrow and umbilical cord blood have been used for decades to treat patients for dozens of diseases. Many more applications are being studied. With advances in the science and medicine of stem cells, experts predict a coming future of regenerative medicine enabled by stem cells, and in a broader array of applications.
Dental stem cells are a newly identified source of adult stem cells and the earliest applications expected are the repair of damaged tooth structures, bone regeneration, and possibly the treatment of neural tissue injury or degenerative diseases (Proceedings of the National Academy of Science, 2003).
Current Adult Stem Cell Applications
Stem Cell Disorders
- Aplastic Anemia (Severe)
- Fanconi Anemia
- Paroxysmal Nocturnal Hemoglobinuria (PNH)
Acute Leukemias
- Acute Lymphoblastic Leukemia (ALL)
- Acute Myelogenous Leukemia (AML)
- Acute Biphenotypic Leukemia
- Acute Undifferentiated Leukemia
Chronic Leukemias
- Chronic Myelogenous Leukemia (CML)
- Chronic Lymphocytic Leukemia (CLL)
- Juvenile Chronic Myelogenous Leukemia (JCML)
- Juvenile Myelomonocytic Leukemia (JMML)
Myeloproliferative Disorders
- Acute Myelofibrosis
- Agnogenic Myeloid Metaplasia (myelofibrosis)
- Polycythemia Vera
- Essential Thrombocythemia
Myelodysplastic Syndromes
- Refractory Anemia (RA)
- Refractory Anemia with Ringed Sideroblasts (RARS)
- Refractory Anemia with Excess Blasts (RAEB)
- Refractory Anemia with Excess Blasts in Transformation (RAEB-T)
- Chronic Myelomonocytic Leukemia (CMML)
Lymphoproliferative Disorders
- Non-Hodgkin's Lymphoma
- Hodgkin's Disease
- Prolymphocytic Leukemia
Inherited Erythrocyte Abnormalities
- Beta Thalassemia Major
- Pure Red Cell Aplasia
- Sickle Cell Disease
Liposomal Storage Diseases
- Mucopolysaccharidoses (MPS)
- Hurler Syndrome (MPS-IH)
- Scheie Syndrome (MPS-IS)
- Hunter's Syndrome (MPS-II)
- Sanfilippo Syndrome (MPS-III)
- Morquio Syndrome (MPS-IV)
- Maroteaux-Lamy Syndrome (MPS-VI)
- Sly Syndrome, Beta-Glucuronidase Deficiency (MPS-VII)
- Adrenoleukodystrophy
- Mucolipidosis II (I-cell Disease)
- Krabbe Disease
- Gaucher's Disease
- Niemann-Pick Disease
- Wolman Disease
- Metachromatic Leukodystrophy
Histiocytic Disorders
- Familial Erythrophagocytic Lymphohistiocytosis
- Histiocytosis-X
- Hemophagocytosis
Phagocyte Disorders
- Chediak-Higashi Syndrome
- Chronic Granulomatous Disease
- Neutrophil Actin Deficiency
- Reticular Dysgenesis
Congenital Immune System Disorders
- Ataxia-Telangiectasia
- Kostmann Syndrome
- Leukocyte Adhesion Deficiency
- DiGeorge Syndrome
- Bare Lymphocyte Syndrome
- Omenn's Syndrome
- Severe Combined Immunodeficiency (SCID)
- SCID with Adenosine Deaminase Deficiency
- Absence of T & B Cells SCID
- Absence of T Cells, Normal B Cell SCID
- Common Variable Immunodeficiency
- Wiskott-Aldrich Syndrome
- X-Linked Lymphoproliferative Disorder
Inherited Platelet Abnormalities
- Amegakaryocytosis / Congenital Thrombocytopenia
Plasma Cell Disorders
- Multiple Myeloma
- Plasma Cell Leukemia
- Waldenstrom's Macroglobulinemia
Other Inherited Disorders
- Lesch-Nyhan Syndrome
- Cartilage-Hair Hypoplasia
- Glanzmann Thrombasthenia
- Osteopetrosis
Other Malignancies
- Breast Cancer
- Ewing Sarcoma
- Neuroblastoma
- Renal Cell Carcinoma
